Molar substitution and C2/C6 ratio of hydroxyethyl starch: influence on blood coagulation †
نویسندگان
چکیده
منابع مشابه
Molar substitution and C2/C6 ratio of hydroxyethyl starch: influence on blood coagulation.
BACKGROUND Development of hydroxyethyl starches (HES) with a low impact on blood coagulation but a long intravascular persistence is of clinical interest. A previous in vitro study showed that low substituted high molecular weight HES does not compromise blood coagulation more than medium molecular weight HES. In the present study we assessed the individual effects on blood coagulation of molar...
متن کاملEffect of progressive haemodilution with hydroxyethyl starch, gelatin and albumin on blood coagulation.
We have compared the effects of progressive (30% and 60%) in vitro haemodilution with hydroxyethyl starch (HES), gelatin (GEL) and albumin (ALB) with haemodilution using 0.9% saline in 96 patients by thrombelastography. Haemodilution with HES, GEL and ALB significantly (P < 0.05) compromised coagulation time (k), angle alpha and maximal amplitude (MA), with HES having the most negative effect a...
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STUDY OBJECTIVES To determine by thrombelastography assessed coagulation, the effects of progressive hemodilution with three intravascular volume expanders. DESIGN Prospective, controlled, whole blood, volumetric ex vivo hemodilution study. SETTING University of Pennsylvania Medical Center Operating Rooms. PATIENTS 60 ASA physical status I and II patients; phlebotomy prior to administrati...
متن کاملHydroxyethyl starch-induced pruritus: clinical characteristics and influence of dose, molecular weight and substitution.
Severe persistent pruritus is a common, but incompletely characterized, complication of hydroxyethyl starch (HES) infusion. This retrospective study aimed to assess HES-induced pruritus by electron microscopic findings, pruritus characteristics, and response to stimuli, and to determine the impact of HES dosage, molecular weight and substitution. Seventy patients with electron micro-scopy-prove...
متن کاملIn Vitro impairment of whole blood coagulation and platelet function by hypertonic saline hydroxyethyl starch
BACKGROUND Hypertonic saline hydroxyethyl starch (HH) has been recommended for first line treatment of hemorrhagic shock. Its effects on coagulation are unclear. We studied in vitro effects of HH dilution on whole blood coagulation and platelet function. Furthermore 7.2% hypertonic saline, 6% hydroxyethylstarch (as ingredients of HH), and 0.9% saline solution (as control) were tested in compara...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 2006
ISSN: 0007-0912
DOI: 10.1093/bja/ael019